Human Growth Hormone: Facts You Need to Know About HGH

Human Growth HormoneOur body is growing and doing self repair all the time. As children our body grows into an adult. As adults, any damaged tissues need to be replaced with new tissues and this requires growth hormone. In this article, we shall take a detailed look at the human growth hormone (HGH), synthetic HGH and its side-effects as well as alternative ways to increase HGH levels in your body.

What is Human Growth Hormone (HGH)?

Growth hormone, also known as somatotropin, is a hormone that is produced by a small gland in the brain called the pituitary gland. More specifically, it is released by the front or anterior aspect of the pituitary gland. From a biochemical perspective, growth hormone is a protein that contains 191 amino acids in its structure and secreted by the cells, termed as somatotrops.

What Does Somatotropin Do?

Human growth hormone plays a primary role in maintaining the various growth related functions of the body. It acts in numerous metabolic functions in the body and stimulates the reproduction of cells. HGH promotes fat breakdown and induces muscle growth. It has some direct and indirect effects on the body, such as:
  • Direct effects occur when the HGH binds to the receptor on the target cells. For instance, fat cells have growth hormones receptors. The growth hormone stimulates them to break down the triglyceride and then finally suppress the ability to absorb and accumulate lipids.
  • Indirect effects are mediated by an insulin growth factor, which is secreted by the liver. Most of the growth promoting effects is due to the IGF-I that acts on the target cells.
It also govermaintain the body weightns the functioning of numerous hormones and enzymes. Other roles of HGH include controlling brain functions and the repair of tissues. Human growth hormone is abundant in children and responsible for their regular growth and development. In adolescents, it works to sustain muscle mass and maintain the body weight. It stimulates the production of energy, provides energy and maintains youthfulness.

HGH Cycles and Secretion Levels

Growth hormone levels vary throughout the day and are found to be at their highest just before a person goes to sleep. Most of the growth hormone secretion in the body occurs during sleep. In the body, growth hormone is released in small pulses at a time. The anterior pituitary responds to certain signals that are released by the hypothalamus in the brain that stimulates it to release the hormone. It rises after trauma, exercise and sleep. The physiology is complicated. After its secretion by the pituitary gland, the body releases it in the pulses. Hypothalamus works to control these pulses. The hypothalamus is responsible for sending signals to shut off and initiate the pulse of growth hormone in the bloodstream. When your body has sufficient growth hormone, the hypothalamus sends a message through somatostatin to stop producing the growth hormone.

Does HGH Decrease With Age?

The release of this hormone is a lot higher in adolescence but decreases as the individual reaches adulthood. From birth, the pituitary gland constantly secretes growth hormone that helps muscles, organs and tissues in the body of a child to mature into that of an adult over a number of years. As adulthood is reached, the amount of HGH that is released is reduced. This is when tissues start to become older and the aging process commences. A 20 to 30-year-old man hosts an average rate of five hundred micrograms of HGH within their blood stream. This rate drops 10 percent every decade, so by the age of 60, a man has only 25 percent of his original human growth hormone rate. The release of growth hormone is also under the influence of a number of external factors. This includes dietary habits, sex of the individual and underlying stress levels.

Why Growth Hormone Is Vital

What people usually know about the human growth hormone is that it makes young individuals grow taller and mature physically. Here are the important functions of HGH that makes it vital for us.
  • Promotes bone health
  • Aids the liver in making glucose from sources that are non-carbohydrates
  • Triggers the growth of all the internal organs excluding the brain
  • Decreases the liver’s glucose uptake
  • Aids in the homeostasis of the body
  • Supports the immune system
  • Promotes fat breakdown
  • Helps in the function of the pancreatic islets and its maintenance
  • Increases the lean muscle mass
  • Enhances the removal of iodine from the T3 and the T4
  • Increases protein synthesis

Growth Hormone Deficiency (GHD)

Growth Hormone Deficiency or GHD is a condition of the pituitary gland wherein the body does not produce adequate amount of growth hormone. The causes include heredity, or as a side effect of tumors and other problems in the pituitary gland. The prevalence of growth hormone deficiency is higher in children. One in every 3,800 infants is born with it. The problem is rare in adults. Around ten in a million grownups have this hormonal problem.

Signs And Symptoms Of HGH Deficiency

Children who do not have enough growth hormones in the body have the following signs and symptoms:
  • Stunted growth, shorter than peers of the same gender
  • Rounder and younger faces than those of the same or younger age
  • Baby fat or chubby abdomen
  • Delayed puberty
Adults with low levels of these hormones may display the following:
  • bone densityLower bone density and more risks for bone fractures as a person ages
  • Lowered stamina, strength and ability to perform exercise without taking rests in between
  • Increased sensitivity to cold or heat
  • Less muscle mass
  • Blood cholesterol makeup changes
  • Decreased libido and sexual function
  • More body fat especially on the waist
  • Fatigue
  • Depression
  • Anxiety
  • Feelings of Isolation

Synthetic HGH and Its Uses

As a prescription to treat GHD, synthetic HGH (somatropin) is offered in an injectable form that is injected into the tissue is just underneath the skin such as the muscle. Care should be taken not to inject a blood vessel. Somatropin should not be confused with somatotropin. The former refers to the generic name for synthetic HGH, while the latter refers to the natural HGH secreted by the pituitary gland. The use of synthetic HGH upon prescription by a registered (licensed) doctor for an approved indication is entirely legal. Prior to prescribing HGH, patients often required certain tests which can be performed by their treating doctor.

Synthetic HGH Treatment For Children and Teenagers

Doctors prescribe HGH injections for young children or teenagers who are struggling with abnormally low levels of bodily growth.  This could be for a variety of reasons, including genetic conditions or a deficiency (low levels or absence) of HGH from birth. Other treatment of childhood conditions include:
  • Turner’s syndrome, a genetic disorder in girls that affects their development
  • Prader-Willi Syndrome,  a rare genetic disorder that causes the person low sex hormone levels, poor tone of the muscles, and always feeling hungry
  • Chronic insufficiency of kidney function
  • Kids that are born small for their gestational age

Synthetic HGH Treatment For Adults

In addition, doctors provide these injections to adults who are suffering from hormonal imbalances caused by damage to the pituitary gland. Various diseases and conditions can affect this gland, and a deficiency of human growth hormone can lead to weakening of the bones and muscles. short bowel syndrome The use of HGH is also approved in certain clinical conditions that include –
  • Long-term kidney disease
  • Short bowel syndrome – this is a clinical condition where there is severe bowel disease and as a result, essential nutrients are not absorbed into the body.
  • Pituitary tumors that result in low amount of HGH secretion
  • HIV illness that results in severe muscle wasting.
But the use of HGH does not end here.

Non-clinical Uses For Synthetic HGH

Those who are into sports and bodybuilding use somatropin to increase their muscle mass. HGH in your body causes IGF-1 to be released from your liver. This process then leads to an uptake of amino acids which can lead to muscle hyperplasia— the splitting of muscle fibers to increase more muscle fibers. This increase of muscle fibers will lead to larger and stronger muscle.

Common Misconceptions About HGH

In last couple of decades, a number of non-clinical use for synthetic HGH have arose due to misinformation or marketing fad. Below is a brief list of some common misconceptions about what synthetic HGH can do.

HGH As An Anti Aging Miracle

In the recent years, human growth hormone has become fairly popular as an anti aging treatment. However, this fact has been subject to constant controversy, with many experts suggesting no action whatsoever of synthetic HGH in slowing down the aging process.

HGH As a Performance Enhancer

Athletes have utilized this drug as an anabolic compound helping them improve their performance and energy levels on the field. However, the use of synthetic HGH in athletes is against the set guidelines of most sport games and can result in them losing their position at a competition.

HGH For Weight Loss

HGH injection prescribed to treat adult patients with GHD helps the patients to increase muscle mass and decrease fat stores. Even so, reduction in body fat is usually fairly small. Such an effect has obviously sparked interest for its use in obese patients but so far the results have not been promising, implying that HGH does not induce sufficient weight loss in obese individuals.

HGH and Height

 increase their overall heightSome individuals take HGH in order to increase their overall height. While the effects may be useful and visible in children, it is not the case in adults. On the contrary, it may cause acromegaly, a severe side effect, where your bones increase in size. A common symptom of acromegaly is enlarged hands and feet.

HGH Injections Available in the Market

There are several brand names for synthetic HGH injections that are currently available. These include-
  • Humatrope – This is a recombinant form of the human growth which is similar to the natural form that is produced in the body.
  • Jintropin – This prescription growth hormone is often used by doctors to help children who are struggling with growth due to an underlying condition.
  • Serostim – this particular prescription drug is often given to patients with underlying AIDS who have severe muscle mass loss.
For a more detailed list, check out “List of Growth Hormones” Another important fact to bear in mind when it comes to HGH injections is the cost. Depending on why the drug is prescribed or for what off label reason it is taken, the costs can vary and can go all the way into thousands of dollars annually.

Is Synthetic HGH Legal and FDA Approved?

The use of HGH in the above clinical conditions is approved by the FDA. However, there are certain situations where it is used that are not approved by the FDA. This includes its use as an anti aging treatment and an anabolic compound (performance enhancing). But this does not mean that it cannot be used as it is still prescribed as an off label indication of its use in certain specialty clinics such as anti aging clinics. In the United States, possession of HGH without a valid doctor’s prescription is illegal. However, there are a number of Internet pharmacies that now ship this product across the patients or individuals who wish to obtain it. Once again, this is against the law and should not be done. Furthermore, one never really knows what the contents of these drugs that are obtained online. They may contain harmful chemicals in them and can be detrimental to an individual’s health and well-being. In addition, if one were to carry these drugs from a foreign country into the United States, they will be stopped by authorities and could face prosecution for carrying a controlled substance.

Does Synthetic HGH Really Work?

The simple answer is yes. It use as a prescription drug has been well established and proven in a number of scientific studies. It can promote muscle healing and enhance growth in children who have low levels, as discussed in the previous section. The effects of HGH are on various systems of the body, and the actual need has to be assessed by physicians before using it. However, you need to be cautious of the side effects, along with the legal and professional implications (for athletes) when purchasing this without prescription and using this with proper guidance. Let’s discuss the possible side effects of synthetic HGH.

Is Synthetic HGH Safe? What Are the Side Effects?

Not all people will have the same reactions to a certain therapy. The effect of certain drug or hormone supplementation is not the same in every person. Therefore, those who are undergoing growth hormone treatment (Synthetic HGH injections) need to watch out for the following:
  • Headache
  • Weakness
  • Nausea and Vomiting
  • Muscle Pain
  • Fatigue
You need to be more concerned if you begin to experience any of the following:
  • Unusual increase in weight
  • More frequent urination than usual
  • Unusual frequent thirst
  • Persistent fatigue
  • Unyielding cold intolerance
  • Repeated fast or slow heartbeat
  • Frequent headaches
  • Ear problems like hearing changes or pain
  • Bone problems like hip or knee pain
  • Severe stomach or abdominal pain
  • Changes in the look of a mole
  • Lung problems such as infections and sleep apnea
  • Tingling of the skin
  • Elevated cholesterol levels
  • Allergic reactions
Other more severe side effects include –
  • Fluid retention in the body (called edema)
  • Severe pain in the joints, muscles and nerves
  • Carpal tunnel syndrome
  • Low Blood Sugar
  • Acromegaly
  • Higher risk of diabetes
  • Formation of and growth of cancerous tumors
  • Breast enlargement in men (called gynaecomastia)
Let’s talk about some of these more severe side effects in details.

1. Fluid Retention (Edema)

One of the side effect is fluid retention and causes swelling of the arms and legs, especially in younger people. This can be a dangerous side effect as it can lead to a higher risk of injury, particularly in athletes. In extreme cases, this can prevent people from walking or exercising normally. In addition, the use of HGH can worsen clinical conditions such as obstructive sleep apnoea. This is a condition where the patient breathing is constantly disturbed at night due to narrowing of the airways when they are asleep. DiabetesThe accumulation of fluid around the neck can result in further narrowing of the airways causing breathing to become more difficult. However, bizarre as it sounds, some people actually wanted this side effect. In older patients, this effect will help to smooth out any wrinkles and give the skin a fuller and younger appearance. This side effect is usually temporary and fade away over time.

2. Severe Pain in the Joints, Muscles and Nerves

Severe pain in the joints and muscles is another issue associated with HGH injections. This can cause problems for athletes or people who enjoy regular exercise. Pain and tension in the joints can prevent people from moving around normally and can interfere in their daily routine in a big way.

3. Carpal Tunnel Syndrome

Carpal tunnel syndrome is a disorder that affects the hands and wrists. It represents itself in the form of pins and needles sensations in this area. The cause of this syndrome is repetitive strain on the wrist. This strain can develop in people who type excessively or put unusual amounts of pressure on their wrists while working or exercising. The carpal tunnel is a passageway in the wrist containing various bones and nerves. carpal tunnel syndromeHGH injections can cause temporary cases of carpal tunnel syndrome, particularly when patients first begin their injection cycles. The symptoms subside after a few weeks. It isn’t one of the most painful or worrying dangers of HGH injections. However, it can be an inconvenience that can prevent you from working or exercising efficiently. This side effect is rather uncommon.

4. Low Blood Sugar (Hypoglycemia)

At the beginning and end of HGH cycles, huge drops in blood sugar levels can be quite common. This can represent a real danger as patients may become lightheaded and even faint due to the lack of sugar in their blood. Hypoglycemia is dangerous if left untreated. Many patients always carry around candy bars or other sugary items of food to replenish their sugar levels during moments of hypoglycemia.

5. Acromegaly

Acromegaly is the enlargement of the extremities, including the chin, brow and fingers. It represents an unwanted side effect as it can drastically alter a person’s appearance. This will only occur with the excessive use of synthetic HGH. So,if you are taking nominal amounts of HGH, there is nothing to fear.

6. Higher Risk of Diabetes

Certain patients may suffer a noticeable increase in their risk of contracting diabetes after taking HGH injections. Studies have shown that acromegaly patients in particular and middle aged women are at a higher risk of this condition.

7. Formation of and Growth of Cancerous Tumors

Human growth hormone works to encourage cell growth. Unfortunately, cancer patients have cancerous cells in their bodies and HGH may encourage these cells to develop as well. This could actually lead to a rapidly-spreading form of cancer that could be dangerous. Studies are ongoing in this area, but cancer patients should avoid taking any form of HGH.

8. Breast Enlargement in Men (Gynaecomastia)

This is a particularly undesirable side effect for male patients. Studies have shown that HGH injections may lead to the development of breasts in certain men. Elderly men are more likely to witness this change, but it can occur at all ages. Naturally, male breasts can be unsightly and drastically reduce a person’s confidence. In conclusion, the use of synthetic HGH as a prescription drug is relatively safe. However, overdosing and long term use of HGH injections may lead to severe complications by putting tremendous pressure on such organs as the liver and heart.

How is Synthetic HGH Different from Steroids?

steroidsIn a nutshell, both of these compounds are structurally very different. While there effects may overlap to an extent, the side-effects that are associated with steroids can also be rather worrying. For example, long-term use of steroids can result in weakness of the bones and a condition called osteoporosis. They can also result in testicular atrophy, meaning the structure and function of the testes can be reduced remarkably. The use of steroids is also banned in the athletic world. There is no clear way to state whether HGH is better than steroids or vice versa. The muscle enlargement and increase in bulk that is seen with HGH use is not associated with an increase in strength. On the contrary, it may be associated with excessive and easy muscle fatigability. Steroids on the other hand can increase muscle strength and overall performance.

What You Should Know About Steroids?

There are two main types of steroids – Anabolic Steroids and Corticosteroids.


These potent chemicals help in the quick reduction of inflammation and swelling. Medical professionals use them extensively to treat inflammatory conditions such as arthritis. These medications are associated to the hormone cortisol, secreted by adrenal glands.

Anabolic Steroids

Anabolic steroids are performance-enhancing medications. Also termed as ergogenic aids, the bodybuilders and athletes use them to improve their overall performance. Anabolic steroids come from male hormones. Known as dihydrotestosterone and testosterone, they increase the formation of protein within the body. They also work to improve stamina, promote bone growth, increase lean muscle mass and enhance physical endurance.

Side Effects of Anabolic Steriods

high blood pressureWith excessive and long-term use, anabolic steroids can cause many severe side effects such as hepato-toxicity, high blood pressure and an increase in low-density lipo-protein. Some other side effects are:
  • Men may suffer from a reduction in sperm count by 90 percent. Other side effects include the swelling of testicles, enlargement of breasts, reduction of testicles and pain while urinating.
  • In women, side effects include the growth of facial hair, changes to the menstrual cycle, hoarse voice and reduction in breast size.
  • Side effects that may occur in both sexes include quick weight gain, acne, nausea, clotting disorders, liver damage, and increased levels of cholesterol, sleep disorders, premature heart attacks and hair loss.
  • Among teenagers, anabolic steroids can cause psychological disorders, mood swings, retarded growth, irritability and suicidal depression.
  • People who abuse steroids suffer from severe withdrawal symptoms upon discontinuing the medication.

Alternatives to Synthetic HGH

This is an overlooked fact, but HGH injections are not the only method for restoring your hormonal balance. You can choose to increase your HGH naturally through eating the right food and lifestyle changes. In addition, various methods do exist that are much safe and less invasive than injections that come with a huge array of nasty side effects. Let’s take a look at a few of these alternatives below.

HGH Patches

supplementsYes, you can actually get a patch for HGH. You can find these patches in homeopathic forms and other variants that contain different natural products like herbs. Either way, they are easy to use and require no prescription whatsoever. A key advantage of these patches is their convenience. You don’t need to worry about taking any supplements or using any sprays. Simply stick the patch on your skin, and leave it there to work its magic. However, there are some problems associated with these patches. Essentially, the body works by producing human growth hormone at certain times of day, not in a constant stream. Patches work by providing a constant stream of elements into the body, which contrasts with the natural function. This can cause some issues as the body is not built to react to this constant input of HGH and may react in bizarre ways.

Homeopathic Sprays

Homeopathic sprays are often entirely natural and completely safe to use. They contain homeopathic variants of human growth hormone, which encourage your pituitary gland to activate and start producing natural HGH. Unfortunately, certain patients can develop a resistance to these sprays that may render them ineffective after a while. However, they can be a powerful and effective method for some people.

HGH Releasers

HGH releasers are available in the form of various products, like tablets or powders that you can take orally. These products don’t actually contain human growth hormone like HGH injections do. As their name suggests, they help your body to release its own natural form of HGH. They do this by stimulating the pituitary gland, which is responsible for producing human growth hormone naturally in humans. These releasers are composed of wholly natural ingredients including plant extracts, herbs and vitamins. These effective ingredients knock your pituitary to boost the level of your HGH production. HGH injectionsAn amazing benefit of these releasers is that they are safe to use with no major risks. They don’t contain any synthetic HGH or other chemicals; thus,there aren’t any dangerous side effects for you to worry about. They are also a much cheaper alternative to HGH injections, which can be extremely pricey and represent a lifelong investment. HGH supplements are available without a prescription, so you can head out and get these supplements without breaking the law.

Try GenF20 Plus HGH Releaser

GenF20 PlusGenF20 is an innovative human growth hormone releaser supplement that contains a recognized formula of peptides, amino acids, and nutrients that are highly safe and effective as well.
  • It is available as supplements so that you don’t have to worry about taking injections.
  • It is also available as a spray that acts as an HGH booster. You can take six sprays daily along with your daily supplement for maximum effectiveness.
  • It is also available as enteric coatings that ensure the ingredients are not affected by your stomach acid.


Human growth hormone releaser is a popular supplement on the market. It should be used on prescription by a physician and its use must be monitored on a regular basis. While it does have a number of beneficial effects, it also has a number of different side-effects and concerns. Legal implications should also be borne in mind when attempting to purchase the product or when carrying the product around. There are a number of different off label uses but once again it is essential to get a physician’s advice and prescription for these.
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